液相分离和质谱联鉴定老鼠以及酵母中的同位素代谢物
发布时间：2020-12-10  作者：wyf  分享到：
液相分离和质谱联鉴定老鼠以及酵母中的同位素代谢物
两种不同的液相分离（亲水性和疏水性）和质谱联用的技术，鉴定老鼠以及酵母中的同位素代谢物。设定了**的鉴定参数，并且对正常酵母和氮饥饿的酵母样品，进行同位素代谢组学鉴定。
反相液相色谱法（reverse-phase liquid chromatography，RPLC）是代谢组学中**和实用的一种LC分离方法。但是他的缺点是对于强极性物质保留较差。亲水相互作用液相色谱（hydrophilic interaction liquid chromatography，HILIC）是近年来色谱领域研究的热点之一。它通过采用强极性度固定相，并且结合高比例有机相和低比例水相作为流动相。此前文章报道的RPLC和HILIC是主要集中在特征峰的数目方面，还没有文章系统比较这两种方法在代谢组学上的鉴定和分析。
统地比较了8种不同条件的RPLC-MS和HILIC-MS方法在代谢组学鉴定上的不同，为代谢组学的鉴定提供新方法。
产品供应：
| cas号 | 中文名称 | 英文名称 |
| 74223-64-6UN | 甲磺隆-D3 | Metsulfuron-methyl-d3 |
| 217487-17-7 | 异丙隆-D6 | Isoproturon-d6 |
| 3811-25-4UN | 氯丙那林-D7 | Clorprenaline-d7 |
| 1794810-59-5 | 盐酸班布特罗-D9 | Bambuterol-d9hydrochloride |
| 苯乙醇胺A-D3 | PhenylethanolamineA-d3 | |
| 1276197-17-1 | 盐酸莱克多巴胺-D6 | Ractopamine-d6hydrochloride |
| 184006-60-8 | 盐酸克伦特罗-D9 | Clenbuterol-d9hydrochloride |
| 1346601-00-0 | 羟甲基克仑特罗-D6 | Hydroxymethylclenbuterol-d6 |
| 1173021-09-4 | 克伦丙罗-D7 | Clenproperol-d7 |
| 1325559-18-9 | 盐酸马喷特罗-D11 | Mapenterolhydrochloride-d11 |
| 1219794-72-5 | 盐酸莱克多巴胺-D3 | Ractopamine-d3hydrochloride |
| 1346599-61-8 | 克伦塞罗-D10 | Clencyclohexerol-d10 |
| 1353940-55-2 | 溴布特罗-D9 | Brombuterol-d9 |
| 1346605-01-3 | 盐酸喷布特罗-D9 | Penbutolol-d9hydrobromide |
| 1325559-14-5 | 盐酸妥布特罗-D9 | Tulobuterol-d9hydrochloride |
| 1246819-04-4 | 西布特罗-D9 | Cimbuterol-d9 |
| 1794793-20-6 | 克仑潘特盐酸盐D5 | Clenpenterold5hydrochloride |
| 497063-94-2 | 沙美特罗-D3 | Salmeterol-d3 |
| 1346599-83-4 | 可尔特罗代谢物-D9 | 3-o-methylcolterol-d9 |
| 1246819-58-8 | 马布特罗-D9 | Mabuterol-d9 |
| 1353867-94-3 | 盐酸溴布特罗-D9 | Brombuterol-d9hydrochloride |
| 1173021-73-2 | 沙丁醇胺-D9 | Racalbuterol-d9 |
| 97825-25-7UN | 莱克多巴胺盐酸盐-D5 | Ractopamine-d5hydrochloride |
| 18559-94-9UN | 沙丁胺醇-D4 | Albuterol-d4 |
| 1217818-36-4 | 齐帕特罗-D7 | Zilpaterol-d7 |
| 1228182-44-2 | 西马特罗D7 | Cimaterol-d7 |
| 1219798-60-3 | 沙丁胺醇-D3 | Salbutamol-d3 |
| 1286129-04-1 | 盐酸非诺特罗-D6 | Fenoterol-d6hydrobromide |
| 203633-19-6 | 多巴胺盐酸盐-D4 | Dopamine-d4hydrochloride |
| 129138-58-5 | 克伦特罗-D9 | Clenbuterol-d9 |
| 1189658-09-0 | 特布他林-D9 | Terbutaline-d9 |
| 1217226-46-4 | 呋喃妥因-13C3 | Nitrofurantoin-13c3 |
| 1015855-64-7 | 呋喃它酮-D5 | Furaltadone-d5 |
| 1217222-76-8 | 呋喃唑酮-D4 | Furazolidone-d4 |
| 1217220-85-3 | 呋喃西林-13C,15N2 | Nitrofurazone-13C,15N2 |
| 957509-31-8 | 呋喃妥因代谢物-13C3 | AHD-13C3 |
| 1007476-86-9 | 呋喃妥因代谢物衍生物-13C3 | 2-NP-AHD-13C3 |
| 1017793-94-0 | 呋喃它酮代谢物-D5 | AMOZ-d5 |
| 1173097-59-0 | 呋喃它酮代谢物衍生物-D5 | 2-NP-AMOZ-d5 |
| 1188331-23-8 | 呋喃唑酮代谢物-D4 | AOZ-d4 |
| 1007478-57-0 | 呋喃唑酮代谢物衍生物-D4 | 2-NP-AOZ-d4 |
| 1173020-16-0 | 呋喃西林代谢物-13C,15N2 | SCA-HCL-13C,15N2 |
| 957509-32-9 | 呋喃西林代谢物衍生物-13C,15N2 | 2-NP-SCA-13C,15N2 |
| 1258668-21-1 | 孔雀石绿-D5苦味酸盐 | Malachitegreen-d5picrate |
| 1173021-13-0 | 隐色孔雀石绿-D6 | Leucomalachitegreen-d6 |
| 1266676-01-0 | 结晶紫-D6 | Crystalviolet-d6 |
| 1173023-92-1 | 隐色结晶紫-D6 | Leucocrystalviolet-d6 |
| 947601-82-3 | 隐性孔雀石绿-D5 | Leucomalachitegreen-d5 |
| 1189863-86-2 | 磺胺吡啶-D4 | Sulfapyridine-d4 |
| 1020719-78-1 | 磺胺嘧啶-D4 | Sulfadiazine-d4 |
| 1020719-84-9 | 磺胺甲基嘧啶-D4 | Sulfamerazined4 |
| 1020719-82-7 | 磺胺二甲基嘧啶-D4 | Sulfamethazine-d4 |
| 1330266-05-1 | 磺胺邻二甲氧嘧啶-D4 | Sulfadoxine-d4 |
| 1020719-80-5 | 磺胺间二甲氧嘧啶-D4 | Sulfadimethoxine-d4 |
| 1286538-12-2 | 磺胺间甲氧基嘧啶-D4 | Sulfamonomethoxine-d4 |
| 1189483-96-2 | 磺胺对甲氧嘧啶-D4 | Sulfameter-d4 |
| 1020719-89-4 | 磺胺噻唑-D4 | Sulfathiazole-d4 |
| 526-08-9UN | 磺胺苯吡唑-D4 | Sulfaphenazole-d4 |
| 1215530-54-3 | 乙酰磺胺甲恶唑-D4 | Acetylsulfamethoxazole-d4 |
| 1020719-86-1 | 磺胺甲基异噁唑-D4 | Sulfamethoxazole-d4 |
| 1329652-02-9 | 磺胺喹恶啉-D4 | Sulfaquinoxaline-d4 |
| 102-65-8UN | 磺胺氯吡嗪-D4 | Sulfachloropyrazine-d4 |
| 80-32-0UN | 磺胺氯哒嗪-D4 | Sulfachloropyridazine-d4 |
| 80-35-3UN | 磺胺甲氧哒嗪-D4 | Sulfamethoxypyridazine-d4 |
| 144-80-9UN | 磺胺醋酰D4 | Sulfacetamide-d4 |
| 144-82-1UN | 磺胺甲噻二唑-D4 | Sulfamethizole-d4 |
| 963-14-4UN | 磺胺乙氧嗪-D4 | Sulfaethoxypyridazine-d4 |
| 515-64-0 | 磺胺二甲异嘧啶-D4 | Sulfisomidine-d4 |
| 63-74-1UN | 磺胺-D4 | Sulfanilamide-d4 |
| 1388717-81-4 | 磺胺二甲恶唑-D4 | Sulfisoxazole-d4 |
| 127-71-9UN | 磺胺苯甲酰-D4 | Sulfabenzamide-d4 |
| 1794753-46-0 | 磺胺硝苯-D4 | Sulfanitran-d4 |
| 93951-89-4 | 邻苯二甲酸二甲酯-3,4,5,6-D4（Dmp） | Dimethylphthalate-3,4,5,6-d4 |
| 93952-12-6 | 邻苯二甲酸二乙酯-3,4,5,6-D4(Dep) | Diethylphthalate-3,4,5,6-d4 |
| 358730-88-8 | 邻苯二甲酸二异丁酯-3,4,5,6-D4(Dibp) | Diisobutylphthalate-3,4,5,6-d4 |
| 93952-11-5 | 邻苯二甲酸二丁酯-3,4,5,6-D4(Dbp) | Dibutylphthalate-3,4,5,6-d4 |
| 1015854-55-3 | 邻苯二甲酸二己酯-3,4,5,6-D4(Dhxp) | Dihexylphthalate-3,4,5,6-d4 |
| 358730-89-9 | 邻苯二甲酸二戊酯-3,4,5,6-D4(Dpp) | Dipentylphthalate-3,4,5,6-d4 |
| 93951-88-3 | 邻苯二甲酸丁苄酯-3,4,5,6-D4(Bbp) | Benzylbutylphthalate-3,4,5,6-d4 |
| 1398065-61-6 | 邻苯二甲酸二苯酯-3,4,5,6-D4(Dphp) | Diphenylphthalate-3,4,5,6-d4 |
| 1202865-43-7 | 邻苯二甲酸二壬酯-3,4,5,6-D4(Dnp) | Dinonylphthalate-3,4,5,6-d4 |
| 93952-13-7 | 邻苯二甲酸二辛酯-3,4,5,6-D4(Dnop) | Dioctylphthalate-3,4,5,6-d4 |
| 1398065-96-7 | 邻苯二甲酸二(2-丁氧基乙基)酯-3,4,5,6-D4(Dbep) | Bis(2-butoxyethyl)phthalate-3,4,5,6-d4 |
| 1398065-54-7 | 邻苯二甲酸二（2-甲氧基）乙酯-3,4,5,6-D4(Dmep) | Bis(2-methoxyethyl)phthalate-3,4,5,6-d4 |
| 1398066-13-1 | 邻苯二甲酸二（4-甲基-2-戊基）酯-3,4,5,6-D4(Bmpp) | Bis(4-methyl-2-pentyl)phthalate-3,4,5,6-d4 |
| 1398066-12-0 | 邻苯二甲酸二（2-乙氧基）乙酯-3,4,5,6-D4(Deep) | Bis(2-ethoxyethyl)phthalate-3,4,5,6-d4 |
| 358731-25-6 | 邻苯二甲酸二环己酯-3,4,5,6-D4(Dchp) | Dicyclohexylphthalate-3,4,5,6-d4 |
| 93951-87-2 | 邻苯二甲酸二（2-乙基己基）酯-3,4,5,6-D4(Dehp) | Bis(2-ethylhexyl)phthalate-3,4,5,6-d4 |
| 1173020-20-6 | 1,3-二氯-2-丙醇-D5（1,3-Dcp） | 1,3-Dichloro-2-propanol-d5 |
| 342611-01-2 | 3-氯-1,2-丙二醇-D5（3-Mcpd） | 3-Chloro-1,2-propanediol |
| 1216764-05-4 | 2-氯-1,3-丙二醇-D5（2-Mcpd） | 2-Chloro-1,3-propanediol |
| 73962-07-9 | 氨基甲酸乙酯-D5 | Ethyl-d5carbamate |
| 752211-63-5 | 苏丹红I-D5 | SudanI-d5 |
| 1398109-09-5 | 苏丹红G-D3 | SudanredG-d3 |
| 1014689-17-8 | 苏丹红Ⅲ-D6 | SudanⅢ-d6 |
| 1398109-08-4 | 二甲基黄-D5 | Dimethylyellow-d5 |
| 362049-51-2 | 对羟基苯甲酸甲酯-D4 | Methyl4-hydroxybenzoate-2,3,5,6-d4 |
| 1219795-53-5 | 乙基4-羟基苯甲酸酯-2,3,5,6-D4 | Ethyl4-hydroxybenzoate-2,3,5,6-d4 |
| 1219802-67-1 | 正丙基-4-羟基苯甲酸酯-2,3,5,6-D4 | N-propyl4-hydroxybenzoate-2,3,5,6-d4 |
| 1219798-67-0 | 正丁基-4-羟基苯甲酸酯-2,3,5,6-D4 | N-butyl4-hydroxybenzoate-2,3,5,6-d4 |
| 1219798-66-9 | 正戊基-4-羟基苯甲酸酯-2,3,5,6-D4 | N-pentyl4-hydroxybenzoate-2,3,5,6-d4 |
| 1219802-40-0 | 苄基-2-羟基苯甲酸酯-3,4,5,6-D4 | Benzyl2-hydroxybenzoate-3,4,5,6-d4 |
| 1329509-49-0 | 盐酸甲基异噻唑啉酮-D3 | Methylisothiazolinone-d3hydrochloride |
| 81103-79-9 | 芴-D10 | Fluorene-d10 |
| 1718-52-1 | 芘-D10 | Pyrene-d10 |
| 1719-06-8 | 蒽-D10 | Anthracene-d10 |
| 1146-65-2 | 萘-D8 | Naphthalene-d8 |
| 1517-22-2 | 菲-D10 | Phenanthrene-d10 |
| 15067-26-2 | 苊-D10 | Acenaphthene-d10 |
| 1520-96-3 | 苝-D12 | Perylene-d12 |
| 1719-03-5 | 屈-D12 | Chrysene-d12 |
| 93951-97-4 | 苊烯-D8 | Acenaphylthene-d8 |
| 63466-71-7 | 苯并[A]芘-D12 | Benzo[a]pyrene-d12 |
| 205440-82-0 | 苯并[E]芘-D12 | Benzo[e]pyrene-d12 |
| 93951-69-0 | 荧蒽-D10 | Fluoranthene-d10 |
| 93951-98-5 | 苯并[B]荧蒽-D12 | Benzo[b]fluoranthene-d12 |
| 93952-01-3 | 苯并[K]荧蒽-D12 | Benzo[k]fluoranthene-d12 |
| 93951-66-7 | 苯并[G,H,I]苝-D12 | Benzo[g,h,i]perylene-d12 |
| 13250-98-1 | 二苯并[A,H]蒽-D14 | Dibenz[a,h]anthracene-d14 |
| 203578-33-0 | 茚并(1.2.3-C.D)芘-D12 | Indeno[1,2,3-cd]pyrene-d12 |
| 1262843-46-8 | 25-羟基维生素D2-D6 | 25-HydroxyvitaminD2-d6 |
| 78782-98-6 | 25-羟基维生素D3-D6 | 25-HydroxyvitaminD3-d6 |
| 1217467-39-4 | 25-羟基维生素D2-D3 | 25-HydroxyvitaminD2-d3 |
| 140710-94-7 | 25-羟基维生素D3-D3 | 25-HydroxyvitaminD3-d3 |
| 18806-29-6 | L-丙氨酸-2,3,3,3-D4 | L-Alanine-d4 |
| 113892-08-3 | α-维生素E-D6 | α-Tocopherol-d6 |
| 372-75-8 | L-瓜氨酸-5,5-D2 | L-Citrulline-5,5-d2 |
| 1233937-39-7 | 维生素K1-D7 | VitaminK1-d7 |
| 87828-86-2 | L-亮氨酸-D3 | L-Leucine-5,5,5-d3 |
| 13010-53-2 | L-蛋氨酸-D3 | L-Methionine-d3 |
| 347841-40-1 | L-鸟氨酸盐酸盐-D6 | L-Ornithine:HCL-3,3,4,4,5,5-d6 |
| 478171-80-1 | 维生素K3-D8 | VitaminK3-d8 |
| 180268-82-0 | L-苯丙氨酸-13C6 | L-Phenylalanine-13C6 |
| 201595-63-3 | L-4-羟基苯基-13C6-丙氨酸 | L-Tyrosine-13C6 |
| 35045-72-8 | L-缬氨酸-D8 | L-Valine-d8 |
| 126827-79-0 | 左旋肉碱-D9 | L-Carnitine-d9 |
| 1334532-17-0 | L-乙酰肉碱盐酸盐-D3 | Acetyl-L-carnitine-d3HCL(n-methyl-d3) |
| 1334532-19-2 | L-丙酰肉碱盐酸盐-D3 | Propionyl-L-carnitine-d3HCL(n-methyl-d3) |
| 1334532-21-6 | L-丁酰肉碱盐酸盐-D3 | Butyryl-L-carnitine-d3HCL(n-methyl-d3) |
| L-异戊酰肉碱盐酸盐-D9 | 2-Methylbutyryl-L-carnitine-d9chloride | |
| L-戊二酰肉碱盐酸盐-D6 | L-Glutarylcarnitine-d6chloride | |
| L-己酰肉碱盐酸盐-D3 | Hexanoyl-L-carnitine-d3HCL(n-methyl-d3) | |
| 1334532-24-9 | L-辛酰肉碱盐酸盐-D3 | Octanoyl-L-carnitine-d3HCL(n-methyl-d3) |
| L-癸酰肉碱盐酸盐-D3 | Decanoyl-L-carnitine-d3HCL(n-methyl-d3) | |
| L-十二碳酰肉碱盐酸盐-D3 | Dodecanoyl-L-carnitine-d3HCL(n-methyl-d3) | |
| 1334532-25-0 | L-十四碳酰肉碱盐酸盐-D3 | Tetradecanoyl-L-carnitine-d3HCL(n-methyl-d3) |
| 1334532-26-1 | L-十六碳酰肉碱盐酸盐-D3 | Palmitoyl-L-carnitine-d3HCL(n-methyl-d3) |
| 2245711-27-5 | L-十八碳酰肉碱盐酸盐-D3 | Octadecanoyl-L-carnitine-d3HCL(n-methyl-d3) |
| 284487-60-1 | DL-3-羟基十四烷酸-2,2,3,4,4-D5 | DL-3-Hydroxymyristicacid-2,2,3,4,4-d5 |
| 506-30-9UN | 二十烷酸-12,12,13,13-D4 | Arachidicacid-12,12,13,13-d4 |
| 232600-70-3 | 二十烷酸-2,2-D2 | Arachidicacid-2,2-d2 |
| 39756-32-6 | 二十烷酸-D39 | Arachidicacid-d39 |
| 156779-02-1 | 丁酸-3,3,4,4,4-D5 | Butyricacid-3,3,4,4,4-d5 |
| 73607-83-7 | 丁酸-D7 | Butyricacid-d7 |
| 92543-08-3 | 胆固醇-2,2,3,4,4,6-D6 | Cholesterol-2,2,3,4,4,6-d6 |
| 83199-47-7 | 胆固醇-25,26,26,26,27,27,27-D7 | Cholesterol-25,26,26,26,27,27,27-d7 |
| 57-88-5UN | 胆固醇-25,26,26,26-D4 | Cholesterol-25,26,26,26-d4 |
| 88170-22-3 | 正癸酸-D19 | Decanoicacid-d19 |
| 102611-15-4 | 正癸酸-D3 | Decanoicacid-d3 |
| 352431-41-5 | 十七烷酸-D33 | Heptadecanoicacid-d33 |
| 202528-95-8 | 十七烷酸-D3 | Heptadecanoicacid-d3 |
| 111-14-8UN | 庚酸-2,2,3,3-D4 | Heptanoicacid-2,2,3,3-d4 |
| 130348-93-5 | 庚酸-D13 | Heptanoicacid-d13 |
| 506-46-7UN | 蜡酸-3,3,5,5-D4 | Hexacosanoicacid-3,3,5,5-d4 |
| 55320-65-5 | 己酸-2,2-D2 | Hexanoicacid-2,2-d2 |
| 95348-44-0 | 己酸-D11 | Hexanoicacid-d11 |
| Hexanoicacid-d3 | ||
| 344298-81-3 | 异戊酸-D9 | Isovalericacid-d9 |
| 59154-43-7 | 月桂酸-D23 | Lauricacid-d23 |
| 79050-22-9 | 月桂酸-D3 | Lauricacid-d3 |
| 327077-03-2 | 肉豆蔻酸-13,13,14,14,14-D5 | Myristicacid-13,13,14,14,14-d5 |
| 60658-41-5 | 肉豆蔻酸-D27 | Myristicacid-d27 |
| 62217-71-4 | 肉豆蔻酸-D3 | Myristicacid-d3 |
| 134646-27-8 | 壬酸-9,9,9-D3 | Nonanoicacid-9,9,9-d3 |
| 130348-94-6 | 壬酸-D17 | Nonanoicacid-d17 |
| 69974-55-6 | 辛酸-D15 | Octanoicacid-d15 |
| 5711-29-5 | 油酸-9,10-D2 | Oleicacid-9,10-d2 |
| 112-80-1UN | 油酸-D33 | Oleicacid-d33 |
| 62689-96-7 | 棕榈酸-2,2-D2 | Palmiticacid-2,2-d2 |
| 39756-30-4 | 棕榈酸-D31 | Palmiticacid-d31 |
| 75736-53-7 | 棕榈酸-D3 | Palmiticacid-d3 |
| 339080-77-2 | 癸二酸-2,2,9,9-D4 | Sebacicacid-2,2,9,9-d4 |
| 211443-83-3 | 硬脂酸-17,17,18,18,18-D5 | Stearicacid-17,17,18,18,18-d5 |
| 17660-51-4 | 硬脂酸-D35 | Stearicacid-d35 |
| α-鼠胆酸-2,2,3,4,4-D5 | α-Muricholicacid-2,2,3,4,4-d5 | |
| β-鼠胆酸-2,2,3,4,4-D5 | β-Muricholicacid-2,2,3,4,4-d5 | |
| γ-鼠胆酸-2,2,3,4,4-D5 | γ-Muricholicacid-2,2,3,4,4-d5 | |
| 鹅去氧胆酸-2,2,3,4,4,6,6,7,8-D9 | Chenodeoxycholicacid-2,2,3,4,4,6,6,7,8-d9 | |
| 鹅去氧胆酸-2,2,3,4,4-D5 | Chenodeoxycholicacid-2,2,3,4,4-d5 | |
| 鹅去氧胆酸-2,2,4,4-D4 | Chenodeoxycholicacid-2,2,4,4-d4 | |
| 53007-09-3 | 胆酸-2,2,3,4,4-D5 | Cholicacid-2,2,3,4,4-d5 |
| 116380-66-6 | 胆酸-2,2,4,4-D4 | Cholicacid-2,2,4,4-d4 |
| 脱氧胆酸-2,2,4,4,11,11-D6 | Deoxycholicacid-2,2,4,4,11,11-d6 | |
| 112076-61-6 | 脱氧胆酸-2,2,4,4-D4 | Deoxycholicacid-2,2,4,4-d4 |
| 甘氨胆酸-2,2,4,4-D4 | Glycocholicacid-2,2,4,4-d4 | |
| 甘氨脱氧胆酸-2,2,4,4,11,11-D6 | Glycodeoxycholicacid-2,2,4,4,11,11-d6 | |
| 1069132-37-1 | 甘氨脱氧胆酸-2,2,4,4-D4 | Glycodeoxycholicacid-2,2,4,4-d4 |
| 2044276-16-4 | 甘氨石胆酸-2,2,4,4-D4 | Glycolithocholicacid-2,2,4,4-d4 |
| 83701-16-0 | 石胆酸-2,2,4,4-D4 | Lithocholicacid-2,2,4,4-d4 |
上述产品仅用于科研，不可用于人体实验！
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