文献：mPEG接枝α-玉米醇溶蛋白聚合物及其制备方法

作者：宋镕光，石彤非，李帆

文献链接：https://xueshu.baidu.com/usercenter/paper/show?paperid=17360jn0wx0t0xd0c11e0v003n660515&site=xueshu_se

摘要：

The present invention relates to an mPEG grafted alpha zein polymer and its preparation method, which solves the technical problem of using zein as a coating material for drugs and nutrients, which is not conducive to controlling drug release and uniform particle size distribution The polymer was first prepared by reacting mPEG with succinic anhydride to obtain mPEG COOH; Then, mPEG COOH was reacted with α - zein to prepare mPEG grafted α - zein polymer The mPEG grafted alpha zein polymer prepared by the method of the present invention can form stable and uniformly sized microspheres (particle size between 80-100nm) after dissolving in water, which are smaller than the particle size of mixed zein and can improve the controlled release and bioavailability of hydrophobic drugs and nutrients

本发明涉及一种mPEG接枝α-玉米醇溶蛋白聚合物及其制备方法,解决现有玉米醇溶蛋白作为药物和营养素的包裹材料,不利于控制药物的释放与粒径分布均一的技术问题.该聚合物首先由mPEG与丁二酸酐反应制备得到mPEG-COOH;再由mPEG-COOH与α-玉米醇溶蛋白反应制备得到mPEG接枝α-玉米醇溶蛋白聚合物.本发明方法制备得到的mPEG接枝α-玉米醇溶蛋白聚合物溶于水后,能够形成稳定存在且尺寸均一的微球(粒径在80-100nm),比混合的玉米醇溶蛋白的粒径小,可提高疏水类药物,营养素的可控释放和生物利用率.

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