文献：mPEG-炔烃的二氧化碳吸附和熔融行为

链接：https://www.sciencedirect.com/science/article/abs/pii/S0896844621000218

作者：S. 洛佩斯，乔丹· 拉莫斯，JM García-Vargas，加西亚 山，JF 罗德里格斯，伊 ·格拉西亚

节选：

抽象的

了解 mPEG-炔烃和超临界 CO 2 (scCO 2 ) 混合物的相行为和研究聚合物熔点的变化是确定适当操作条件和开发高压工艺的必要先决条件，以便获得 mPEG-炔烃与药物或蛋白质的共轭物。在这项工作中，观察到吸附 CO 2会导致 mPEG-炔烃的熔点温度逐渐降低。使用改良的克劳修斯-克拉珀龙方程将获得的熔化温度关联起来。使用采用静态方法的可变体积观察室确定CO 2在 mPEG-炔烃中的平衡吸附。这些实验是在 308 至 318 K 的温度范围内以及 8–17 MPa 的压力下进行的。评估了亨利定律、双模式、桑切斯-拉孔布状态方程和启发式模型的预测能力。

Abstract

The understanding of the phase behaviour of the mixture mPEG-alkyne and supercritical CO2 (scCO2) and the study of the variation of the polymer melting point are essential prerequisites in order to determine appropriate operating conditions and develop high pressure processes that allow the obtention of a conjugate mPEG-alkyne with a drug or a protein. In this work, it was observed a progressive decrease of the melting point temperature of mPEG-alkyne induced by the adsorption of CO2. The obtained melting temperatures were correlated using a modification of the Clausius Clapeyron equation. The equilibrium sorption of CO2 into mPEG-alkyne was determined with a variable-volume view cell employing a static method. These experiments were carried out in the temperature range 308 and 318 K, and at 8–17 MPa of pressure. The prediction capabilities of the models of Henry’s Law, Dual-Mode, Sanchez Lacombe Equation of State and Heuristic Model was evaluated.

西安齐岳生物提供相关产品：

DSPE-Cap-Biotin

DMG-PEG2000

C18-PEGn-OPSS

DSPE-PEG-NTA-NI

DPPE-PEG-NH2

DSPE-PEG-COOH（二硬脂酰基磷脂酰乙醇胺-聚乙二醇-羧基)

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