文献：Targeted folic acid-PEG nanoparticles for noninvasive imaging of folate receptor by MRI

作者：Ting-Jung Chen, Tsan-Hwang Cheng, Yu-Chin Hung, Kuei-Tang Lin, Gin-Chung Liu, Yun-Ming Wang

文献链接：https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.a.31752

摘要：

The surface of superparamagnetic iron oxide nanoparticles (SPIO) with different molecular weight of poly(ethylene glycol) (PEG) and folic acid (FA) were synthesized. The SPIO-PEG-FA nanoparticles are well-dispersed and have good stability in various pH solutions. The lack of hysterestis and remanence at ambient temperatures is characteristic of superparamagnetic materials for SPIO-PEG-FA. The uptake by macrophage for SPIO-PEG-FA is lower than that of Feridex I.V. even at higher concentration. Internalization of SPIO-PEG-FA in targeted cells (KB cells) was observed by flow-cytometric analysis and in vitro MR imaging. The intensity change of positive KB cell tumor (−20 to 25%) is significantly lower than that of negative HT-1080 cell tumor from precontrast to postcontrast images of the tumor by in vivo MR imaging. These preliminary results demonstrated that SPIO-PEG-FA have the ability to target folate receptor.  

合成了不同分子量聚乙二醇（PEG）和叶酸（FA）的超顺磁性氧化铁纳米粒子（SPIO）表面。SPIO-PEG-FA纳米粒子分散良好，在各种pH溶液中具有良好的稳定性。

在环境温度下缺乏磁滞和剩磁是SPIO-PEG-FA的超顺磁性材料的特征。即使在更高的浓度下，巨噬细胞对SPIO-PEG-Fe的摄取也低于Feridex I.V。通过流式细胞术分析和体外MR成像观察SPIO-PEG-FA在靶细胞（KB细胞）中的内化。

通过体内MR成像，从肿瘤的造影前图像到造影后图像，阳性KB细胞肿瘤的强度变化（-20%至25%）明显低于阴性HT-1080细胞肿瘤。这些初步结果表明，SPIO-PEG-FA具有靶向叶酸受体的能力。

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