文献：新型 RGD-脂质共轭修饰脂质体用于增强人视网膜色素上皮细胞中 siRNA 的递送

链接：https://www.tandfonline.com/doi/full/10.2147/IJN.S24447

作者：陈成伟，卢大文，叶明公，萧嘉阳&蒋介石

节选：

合成了一种新型功能性脂质DSPE-PEG-RGD，其结构为Arg(R)-Gly(G)-Asp(D)肽基与1,2-二硬脂酰-sn-甘油-3-磷酸乙醇胺-N-[马来酰亚胺（聚乙二醇）-2000]偶联。该脂质体用于制备载siRNA的RGD-PEG化脂质体，以增强视网膜色素上皮细胞对siRNA的摄取。制备了分别含有1 mol%和5 mol% PEG化脂质以及1 mol%和5 mol% RGD-PEG化脂质的多种脂质体。

A novel functional lipid, DSPE-PEG-RGD, a Arg(R)-Gly(G)-Asp(D) motif peptide conjugated to 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine- N-[maleimide (polyethylene glycol)-2000], was synthesized for the preparation of siRNA-loaded RGD-PEGylated liposomes to enhance uptake of encapsulated siRNA in retinal pigment epithelial cells. Various liposomes, with 1 mol% and 5 mol% PEGylated lipid or 1 mol% and 5 mol% RGD-PEGylated lipid, were fabricated.

西安齐岳生物提供相关产品：

DSPE-PEG-6-O-glucose

Cy3-iRGD-PEG-DSPE

RGD-PEG-COOH

DOPE-PEI

cRGD-PEG-COOH

mPEG-Cholesterol (mPEG-CLS)

DPPE-PEG2-NH-Mal

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